Clinical and Functional Characterization of Atypical KRAS/NRAS Mutations in Metastatic Colorectal Cancer Read More →
Abstract 1092: A systematic analysis of BRAF mutations and their sensitivity to different BRAF inhibitors Read More →
Interim results from a phase 1/2 precision medicine study of PLX8394- a next generation BRAF inhibitor Read More →
Functional measurement of mitogen-activated protein kinase pathway activation predicts responsiveness of RAS-mutant cancers to MEK inhibitors Read More →
Phase 1B Study of Vemurafenib in Combination with Irinotecan and Cetuximab in Patients with Metastatic Colorectal Cancer with BRAF V600E Mutation Read More →
Subclonal Therapy by Two EGFR TKIs Guided by Sequential Plasma Cell-free DNA in EGFR-Mutated Lung Cancer Read More →
SILAC identifies LAD1 as a filamin-binding regulator of actin dynamics in response to EGF and a marker of aggressive breast tumors Read More →
Revisited analysis of a SHIVA01 trial cohort using functional mutational analyses successfully predicted treatment outcome Read More →
CRISPR-Directed In Vitro Gene Editing of Plasmid DNA Catalyzed by Cpf1 (Cas12a) Nuclease and a Mammalian Cell-Free Extract Read More →
CRISPR-Directed Gene Editing Catalyzes Precise Gene Segment Replacement In Vitro Enabling a Novel Method for Multiplex Site-Directed Mutagenesis Read More →
Identification of osimertinib-resistant EGFR L792 mutations by cfDNA sequencing: oncogenic activity assessment and prevalence in large cfDNA cohort Read More →
A Novel System for Functional Determination of Variants of Uncertain Significance using Deep Convolutional Neural Networks Read More →
gRNA Sequence Heterology Tolerance Catalyzed by CRISPR/Cas in an In Vitro Homology-Directed Repair Reaction Read More →
